Prediction Atlético Nacional vs São Paulo season 2025 – Betting Tips for the Copa Libertadores on 13/08/2025

As the Copa Libertadores reaches its electrifying Round of 16, the upcoming clash between Atlético Nacional and São Paulo promises to be a thrilling encounter. Scheduled to take place at the vibrant Estadio Atanasio Girardot in Medellín, Colombia, this matchup will feature two teams brimming with confidence, both having demonstrated their prowess in recent matches.

Atlético Nacional: A Force At Home

Atlético Nacional heads into this fixture on the back of an impressive run, having won three out of their last five matches, including a commanding 3-0 victory against Alianza Petrolera just days ago. They remain a potent attacking unit, scoring a total of seven goals in their last five outings and managing to keep two clean sheets during that stretch. With an 83% shot accuracy at home, they clearly have capitalized on their opportunities. Their only hiccup came with a 0-0 draw against Tolima, indicating they can be tough to break down.

With a home win probability set at approximately 45.45%, Atlético Nacional's strong record, coupled with their successful history against São Paulo—having previously beaten them 2-1 in the semi-finals of the Copa Libertadores in 2016—adds to their hopeful outcome for this crucial match.

São Paulo: Visitors in High Spirits

On the other side, São Paulo arrives in Medellín riding high after securing victories in their last four matches, including a comfortable 2-0 win against Vitória. Their form showcases a team that not only knows how to score—totaling five goals away from home—but also one that has exhibited defensive resilience, allowing no goals in their last two away fixtures. São Paulo's approach has typically featured a blend of tactical discipline and an eye for attacking opportunities, evident in their attacking statistics which reveal 20 shots on target in recent outings.

Despite the solid momentum, the odds of a São Paulo victory stand at 28.57%, hinting that the away side may face an uphill encounter against the passionate home crowd of Atlético Nacional.

Betting Tips to Consider

Given the statistics and the current forms of both teams, the recommended bet for this match is to back Atlético Nacional to win. The home squad appears to not only be in better overall form but also seems to thrive in front of their supporters.

Backing Nacional at odds of 2.20 is a sound decision considering their strong offensive capabilities and ability to keep clean sheets. As they take to their home turf, expect their attacking flair to lead them to victory in this all-important knockout stage match. The excitement is palpable as these two giants of South American football clash, and it promises to be a night of unforgettable action in Medellín!